Beilstein J. Org. Chem.2017,13, 1907–1931, doi:10.3762/bjoc.13.186
-workers have successfully demonstrated rhodium(III)-catalyzed C–H bond functionalization under mechanochemical conditions [182]. Advantageously, the developed method adopted mild reaction conditions, i.e., in solvent-freemedium and at room temperature. It required a minimum amount of toxic metal salt of
Beilstein J. Org. Chem.2014,10, 2654–2657, doi:10.3762/bjoc.10.278
with a promising yield.
Keywords: fatty ester; green chemistry; lipase; mono-substituted amphiphilic cyclodextrins; peptide Coupling; solvent-freemedium; transesterification; Introduction
Cyclodextrins (CDs) are sustainable compounds which are particularly interesting in the frame of pharmaceutical
various lipases in solventfreemedium was reported [13]. Using specific experimental conditions such as an open reactor leads to a better yield [9][14], however, the reaction time is still long for the synthesis of bicatenar glycerolipidyl derivatives (5 days, 54% for the reaction using ethyl stearate